H2N2V1, Main, Exploration, bibRecord, 000441

Identification of microRNAs in Throat Swab as the Biomarkers for Diagnosis of Influenza

Identifieur interne : 000441 ( Main/Exploration ); précédent : 000440; suivant : 000442

Identification of microRNAs in Throat Swab as the Biomarkers for Diagnosis of Influenza

Source :

International Journal of Medical Sciences [ 1449-1907 ] ; 2016.

RBID : PMC:4747873

Abstract

Background: Influenza is a serious worldwide disease that captures global attention in the past few years after outbreaks. The recent discoveries of microRNA (miRNA) and its unique expression profile in influenza patients have offered a new method for early influenza diagnosis. The aim of this study was to examine the utility of miRNAs for the diagnosis of influenza.

Methods: Thirteen selected miRNAs were investigated with the hosts' throat swabs (25 H1N1, 20 H3N2, 20 influenza B and 21 healthy controls) by real-time quantitative polymerase chain reaction (RT-qPCR) using U6 snRNA as endogenous control for normalization, and receiver operating characteristic (ROC) curve/Area under curve (AUC) for analysis.

Results: miR-29a-3p, miR-30c-5p, miR-34c-3p and miR-181a-5p are useful biomarkers for influenza A detection; and miR-30c-5p, miR-34b-5p, miR-205-5p and miR-449b-5p for influenza B detection. Also, use of both miR-30c-5p and miR-34c-3p (AUC=0.879); and miR-30c-5p and miR-449b-5p (AUC=0.901) are better than using one miRNA to confirm influenza A and influenza B infection, respectively.

Conclusions: Given its simplicity, non-invasiveness and specificity, we found that the throat swab-derived miRNAs miR-29a-3p, miR-30c-5p, miR-34b-5p, miR-34c-3p, miR-181a-5p, miR-205-5p and miR-449b-5p are a useful tool for influenza diagnosis on influenza A and B.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747873

DOI: 10.7150/ijms.13301
PubMed: 26917988
PubMed Central: 4747873

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of microRNAs in Throat Swab as the Biomarkers for Diagnosis of Influenza</title>
<author><name sortKey="Peng, Fang" sort="Peng, Fang" uniqKey="Peng F" first="Fang" last="Peng">Fang Peng</name>
<affiliation wicri:level="3"><nlm:aff id="A1">1. Department of Health Inspection and Quarantine, School of Public Health, Sun Yat-sen University, Guangzhou, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>1. Department of Health Inspection and Quarantine, School of Public Health, Sun Yat-sen University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="He, Jianan" sort="He, Jianan" uniqKey="He J" first="Jianan" last="He">Jianan He</name>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Loo, Jacky Fong Chuen" sort="Loo, Jacky Fong Chuen" uniqKey="Loo J" first="Jacky Fong Chuen" last="Loo">Jacky Fong Chuen Loo</name>
<affiliation wicri:level="4"><nlm:aff id="A3">3. Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>3. Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yao, Jingyu" sort="Yao, Jingyu" uniqKey="Yao J" first="Jingyu" last="Yao">Jingyu Yao</name>
<affiliation wicri:level="1"><nlm:aff id="A4">4. Guangdong Medical University, Zhanjiang, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>4. Guangdong Medical University, Zhanjiang</wicri:regionArea>
<wicri:noRegion>Zhanjiang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shi, Lei" sort="Shi, Lei" uniqKey="Shi L" first="Lei" last="Shi">Lei Shi</name>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Chunxiao" sort="Liu, Chunxiao" uniqKey="Liu C" first="Chunxiao" last="Liu">Chunxiao Liu</name>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhao, Chunzhong" sort="Zhao, Chunzhong" uniqKey="Zhao C" first="Chunzhong" last="Zhao">Chunzhong Zhao</name>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xie, Weidong" sort="Xie, Weidong" uniqKey="Xie W" first="Weidong" last="Xie">Weidong Xie</name>
<affiliation wicri:level="3"><nlm:aff id="A5">5. Shenzhen Key Lab of Health Science and Technology, Division of Life Sciences & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>5. Shenzhen Key Lab of Health Science and Technology, Division of Life Sciences & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shao, Yonghong" sort="Shao, Yonghong" uniqKey="Shao Y" first="Yonghong" last="Shao">Yonghong Shao</name>
<affiliation wicri:level="3"><nlm:aff id="A6">6. College of Optoelectronics Engineering, Key Laboratory of Optoelectronic Devices and Systems, Ministry of Education and Guangdong Province, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>6. College of Optoelectronics Engineering, Key Laboratory of Optoelectronic Devices and Systems, Ministry of Education and Guangdong Province, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kong, Siu Kai" sort="Kong, Siu Kai" uniqKey="Kong S" first="Siu Kai" last="Kong">Siu Kai Kong</name>
<affiliation wicri:level="4"><nlm:aff id="A3">3. Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>3. Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gu, Dayong" sort="Gu, Dayong" uniqKey="Gu D" first="Dayong" last="Gu">Dayong Gu</name>
<affiliation wicri:level="3"><nlm:aff id="A1">1. Department of Health Inspection and Quarantine, School of Public Health, Sun Yat-sen University, Guangzhou, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>1. Department of Health Inspection and Quarantine, School of Public Health, Sun Yat-sen University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26917988</idno>
<idno type="pmc">4747873</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747873</idno>
<idno type="RBID">PMC:4747873</idno>
<idno type="doi">10.7150/ijms.13301</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000074</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000074</idno>
<idno type="wicri:Area/Pmc/Curation">000074</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000074</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000319</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000319</idno>
<idno type="wicri:Area/Ncbi/Merge">000C63</idno>
<idno type="wicri:Area/Ncbi/Curation">000C63</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000C63</idno>
<idno type="wicri:Area/Main/Merge">000441</idno>
<idno type="wicri:Area/Main/Curation">000441</idno>
<idno type="wicri:Area/Main/Exploration">000441</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of microRNAs in Throat Swab as the Biomarkers for Diagnosis of Influenza</title>
<author><name sortKey="Peng, Fang" sort="Peng, Fang" uniqKey="Peng F" first="Fang" last="Peng">Fang Peng</name>
<affiliation wicri:level="3"><nlm:aff id="A1">1. Department of Health Inspection and Quarantine, School of Public Health, Sun Yat-sen University, Guangzhou, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>1. Department of Health Inspection and Quarantine, School of Public Health, Sun Yat-sen University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="He, Jianan" sort="He, Jianan" uniqKey="He J" first="Jianan" last="He">Jianan He</name>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Loo, Jacky Fong Chuen" sort="Loo, Jacky Fong Chuen" uniqKey="Loo J" first="Jacky Fong Chuen" last="Loo">Jacky Fong Chuen Loo</name>
<affiliation wicri:level="4"><nlm:aff id="A3">3. Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>3. Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yao, Jingyu" sort="Yao, Jingyu" uniqKey="Yao J" first="Jingyu" last="Yao">Jingyu Yao</name>
<affiliation wicri:level="1"><nlm:aff id="A4">4. Guangdong Medical University, Zhanjiang, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>4. Guangdong Medical University, Zhanjiang</wicri:regionArea>
<wicri:noRegion>Zhanjiang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shi, Lei" sort="Shi, Lei" uniqKey="Shi L" first="Lei" last="Shi">Lei Shi</name>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Chunxiao" sort="Liu, Chunxiao" uniqKey="Liu C" first="Chunxiao" last="Liu">Chunxiao Liu</name>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhao, Chunzhong" sort="Zhao, Chunzhong" uniqKey="Zhao C" first="Chunzhong" last="Zhao">Chunzhong Zhao</name>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xie, Weidong" sort="Xie, Weidong" uniqKey="Xie W" first="Weidong" last="Xie">Weidong Xie</name>
<affiliation wicri:level="3"><nlm:aff id="A5">5. Shenzhen Key Lab of Health Science and Technology, Division of Life Sciences & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>5. Shenzhen Key Lab of Health Science and Technology, Division of Life Sciences & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shao, Yonghong" sort="Shao, Yonghong" uniqKey="Shao Y" first="Yonghong" last="Shao">Yonghong Shao</name>
<affiliation wicri:level="3"><nlm:aff id="A6">6. College of Optoelectronics Engineering, Key Laboratory of Optoelectronic Devices and Systems, Ministry of Education and Guangdong Province, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>6. College of Optoelectronics Engineering, Key Laboratory of Optoelectronic Devices and Systems, Ministry of Education and Guangdong Province, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kong, Siu Kai" sort="Kong, Siu Kai" uniqKey="Kong S" first="Siu Kai" last="Kong">Siu Kai Kong</name>
<affiliation wicri:level="4"><nlm:aff id="A3">3. Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>3. Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gu, Dayong" sort="Gu, Dayong" uniqKey="Gu D" first="Dayong" last="Gu">Dayong Gu</name>
<affiliation wicri:level="3"><nlm:aff id="A1">1. Department of Health Inspection and Quarantine, School of Public Health, Sun Yat-sen University, Guangzhou, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>1. Department of Health Inspection and Quarantine, School of Public Health, Sun Yat-sen University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2. Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">International Journal of Medical Sciences</title>
<idno type="eISSN">1449-1907</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Background: </bold>
Influenza is a serious worldwide disease that captures global attention in the past few years after outbreaks. The recent discoveries of microRNA (miRNA) and its unique expression profile in influenza patients have offered a new method for early influenza diagnosis. The aim of this study was to examine the utility of miRNAs for the diagnosis of influenza.</p>
<p><bold>Methods: </bold>
Thirteen selected miRNAs were investigated with the hosts' throat swabs (25 H1N1, 20 H3N2, 20 influenza B and 21 healthy controls) by real-time quantitative polymerase chain reaction (RT-qPCR) using U6 snRNA as endogenous control for normalization, and receiver operating characteristic (ROC) curve/Area under curve (AUC) for analysis.</p>
<p><bold>Results: </bold>
miR-29a-3p, miR-30c-5p, miR-34c-3p and miR-181a-5p are useful biomarkers for influenza A detection; and miR-30c-5p, miR-34b-5p, miR-205-5p and miR-449b-5p for influenza B detection. Also, use of both miR-30c-5p and miR-34c-3p (AUC=0.879); and miR-30c-5p and miR-449b-5p (AUC=0.901) are better than using one miRNA to confirm influenza A and influenza B infection, respectively.</p>
<p><bold>Conclusions: </bold>
Given its simplicity, non-invasiveness and specificity, we found that the throat swab-derived miRNAs miR-29a-3p, miR-30c-5p, miR-34b-5p, miR-34c-3p, miR-181a-5p, miR-205-5p and miR-449b-5p are a useful tool for influenza diagnosis on influenza A and B.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Fu, C" uniqKey="Fu C">C Fu</name>
</author>
<author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Jq" uniqKey="Zhao J">JQ Zhao</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Ragupathy, V" uniqKey="Ragupathy V">V Ragupathy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Terrier, Jt" uniqKey="Terrier J">JT Terrier</name>
</author>
<author><name sortKey="Carron, C" uniqKey="Carron C">C Carron</name>
</author>
<author><name sortKey="Marcel, V" uniqKey="Marcel V">V Marcel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuo, Rl" uniqKey="Kuo R">RL Kuo</name>
</author>
<author><name sortKey="Yang, Sl" uniqKey="Yang S">SL Yang</name>
</author>
<author><name sortKey="Liu, Yc" uniqKey="Liu Y">YC Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ledesma, J" uniqKey="Ledesma J">J Ledesma</name>
</author>
<author><name sortKey="Pozo, F" uniqKey="Pozo F">F Pozo</name>
</author>
<author><name sortKey="Reina, G" uniqKey="Reina G">G Reina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Peng, H" uniqKey="Peng H">H Peng</name>
</author>
<author><name sortKey="Tao, Q" uniqKey="Tao Q">Q Tao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kis, Z" uniqKey="Kis Z">Z Kis</name>
</author>
<author><name sortKey="Jones, J" uniqKey="Jones J">J Jones</name>
</author>
<author><name sortKey="Creanga, A" uniqKey="Creanga A">A Creanga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ghebremedhin, B" uniqKey="Ghebremedhin B">B Ghebremedhin</name>
</author>
<author><name sortKey="Engelmann, I" uniqKey="Engelmann I">I Engelmann</name>
</author>
<author><name sortKey="Konig, W" uniqKey="Konig W">W Konig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
<author><name sortKey="Ouyang, X" uniqKey="Ouyang X">X Ouyang</name>
</author>
<author><name sortKey="Jiang, X" uniqKey="Jiang X">X Jiang</name>
</author>
<author><name sortKey="Gu, D" uniqKey="Gu D">D Gu</name>
</author>
<author><name sortKey="Lin, Y" uniqKey="Lin Y">Y Lin</name>
</author>
<author><name sortKey="Kong, Sk" uniqKey="Kong S">SK Kong</name>
</author>
<author><name sortKey="Xie, W" uniqKey="Xie W">W Xie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Wc" uniqKey="Zhang W">WC Zhang</name>
</author>
<author><name sortKey="Liu, Jb" uniqKey="Liu J">JB Liu</name>
</author>
<author><name sortKey="Wang, Gs" uniqKey="Wang G">GS Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, L" uniqKey="Song L">L Song</name>
</author>
<author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name>
</author>
<author><name sortKey="Gao, S" uniqKey="Gao S">S Gao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name>
</author>
<author><name sortKey="Qi, Y" uniqKey="Qi Y">Y Qi</name>
</author>
<author><name sortKey="Ge, A" uniqKey="Ge A">A Ge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, T" uniqKey="He T">T He</name>
</author>
<author><name sortKey="Chen, Hp" uniqKey="Chen H">HP Chen</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salazar, C" uniqKey="Salazar C">C Salazar</name>
</author>
<author><name sortKey="Nagadia, R" uniqKey="Nagadia R">R Nagadia</name>
</author>
<author><name sortKey="Pandit, P" uniqKey="Pandit P">P Pandit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, Nj" uniqKey="Park N">NJ Park</name>
</author>
<author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name>
</author>
<author><name sortKey="Elashoff, D" uniqKey="Elashoff D">D Elashoff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Patel, Rs" uniqKey="Patel R">RS Patel</name>
</author>
<author><name sortKey="Jakymiw, A" uniqKey="Jakymiw A">A Jakymiw</name>
</author>
<author><name sortKey="Yao, B" uniqKey="Yao B">B Yao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Wd" uniqKey="Wu W">WD Wu</name>
</author>
<author><name sortKey="Hou, Wj" uniqKey="Hou W">WJ Hou</name>
</author>
<author><name sortKey="Wu, Zf" uniqKey="Wu Z">ZF Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name>
</author>
<author><name sortKey="Xu, W" uniqKey="Xu W">W Xu</name>
</author>
<author><name sortKey="Abernathy, Es" uniqKey="Abernathy E">ES Abernathy</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Loveday, Ek" uniqKey="Loveday E">EK Loveday</name>
</author>
<author><name sortKey="Diederich, S" uniqKey="Diederich S">S Diederich</name>
</author>
<author><name sortKey="Pasick, J" uniqKey="Pasick J">J Pasick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Chan, Ey" uniqKey="Chan E">EY Chan</name>
</author>
<author><name sortKey="1 Li, Jn" uniqKey="1 Li J">JN 1 Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogers, Jv" uniqKey="Rogers J">JV Rogers</name>
</author>
<author><name sortKey="Price, Ja" uniqKey="Price J">JA Price</name>
</author>
<author><name sortKey="Wendling, Mqs" uniqKey="Wendling M">MQS Wendling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, H" uniqKey="Song H">H Song</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lam, Wy" uniqKey="Lam W">WY Lam</name>
</author>
<author><name sortKey="Yeung, Acm" uniqKey="Yeung A">ACM Yeung</name>
</author>
<author><name sortKey="Ngai Karry, Lk" uniqKey="Ngai Karry L">LK Ngai Karry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loveday, Ek" uniqKey="Loveday E">EK Loveday</name>
</author>
<author><name sortKey="Diederich, S" uniqKey="Diederich S">S Diederich</name>
</author>
<author><name sortKey="Pasick, J" uniqKey="Pasick J">J Pasick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Othumpangat, S" uniqKey="Othumpangat S">S Othumpangat</name>
</author>
<author><name sortKey="Noti, Jd" uniqKey="Noti J">JD Noti</name>
</author>
<author><name sortKey="Beezhold, Dh" uniqKey="Beezhold D">DH Beezhold</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Zh" uniqKey="Wu Z">ZH Wu</name>
</author>
<author><name sortKey="Li, P" uniqKey="Li P">P Li</name>
</author>
<author><name sortKey="Zhang, Cf" uniqKey="Zhang C">CF Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loo, Jf" uniqKey="Loo J">JF Loo</name>
</author>
<author><name sortKey="Wang, Ss" uniqKey="Wang S">SS Wang</name>
</author>
<author><name sortKey="Peng, F" uniqKey="Peng F">F Peng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Patel, P" uniqKey="Patel P">P Patel</name>
</author>
<author><name sortKey="Ansari, My" uniqKey="Ansari M">MY Ansari</name>
</author>
<author><name sortKey="Bapat, S" uniqKey="Bapat S">S Bapat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Buggele, Wa" uniqKey="Buggele W">WA Buggele</name>
</author>
<author><name sortKey="Krause, Ke" uniqKey="Krause K">KE Krause</name>
</author>
<author><name sortKey="Horvath, Cm" uniqKey="Horvath C">CM Horvath</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Guangdong</li>
</region>
<settlement><li>Jiangmen</li>
<li>Sha Tin</li>
<li>Shenzhen</li>
</settlement>
<orgName><li>Université chinoise de Hong Kong</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Peng, Fang" sort="Peng, Fang" uniqKey="Peng F" first="Fang" last="Peng">Fang Peng</name>
</region>
<name sortKey="Gu, Dayong" sort="Gu, Dayong" uniqKey="Gu D" first="Dayong" last="Gu">Dayong Gu</name>
<name sortKey="Gu, Dayong" sort="Gu, Dayong" uniqKey="Gu D" first="Dayong" last="Gu">Dayong Gu</name>
<name sortKey="He, Jianan" sort="He, Jianan" uniqKey="He J" first="Jianan" last="He">Jianan He</name>
<name sortKey="Kong, Siu Kai" sort="Kong, Siu Kai" uniqKey="Kong S" first="Siu Kai" last="Kong">Siu Kai Kong</name>
<name sortKey="Liu, Chunxiao" sort="Liu, Chunxiao" uniqKey="Liu C" first="Chunxiao" last="Liu">Chunxiao Liu</name>
<name sortKey="Loo, Jacky Fong Chuen" sort="Loo, Jacky Fong Chuen" uniqKey="Loo J" first="Jacky Fong Chuen" last="Loo">Jacky Fong Chuen Loo</name>
<name sortKey="Peng, Fang" sort="Peng, Fang" uniqKey="Peng F" first="Fang" last="Peng">Fang Peng</name>
<name sortKey="Shao, Yonghong" sort="Shao, Yonghong" uniqKey="Shao Y" first="Yonghong" last="Shao">Yonghong Shao</name>
<name sortKey="Shi, Lei" sort="Shi, Lei" uniqKey="Shi L" first="Lei" last="Shi">Lei Shi</name>
<name sortKey="Xie, Weidong" sort="Xie, Weidong" uniqKey="Xie W" first="Weidong" last="Xie">Weidong Xie</name>
<name sortKey="Yao, Jingyu" sort="Yao, Jingyu" uniqKey="Yao J" first="Jingyu" last="Yao">Jingyu Yao</name>
<name sortKey="Zhao, Chunzhong" sort="Zhao, Chunzhong" uniqKey="Zhao C" first="Chunzhong" last="Zhao">Chunzhong Zhao</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000441 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000441 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4747873
   |texte=   Identification of microRNAs in Throat Swab as the Biomarkers for Diagnosis of Influenza
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26917988" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Identification of microRNAs in Throat Swab as the Biomarkers for Diagnosis of Influenza

Identification of microRNAs in Throat Swab as the Biomarkers for Diagnosis of Influenza

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.